A subgroup in the trial noted that docosanol stopped cold sore episodes from progressing to the blister stage in 34% of patients who applied it at the early sign of an outbreak (redness) compared to 23% in the equivalent placebo group.
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Headache was the most common side effect, but it occurred with the same frequency in patients treated with placebo as with docosanol.
Docosanol works by inhibiting fusion between the human cell plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication. Since the
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